Capelli group publish paper in Genetics

Montinaro F, Busby GBJ, Gonzalez-Santos M, Oosthuitzen O, Oosthutizen E, Anagnostou P, Destro-Bisol G, Pascali VL, Capelli C (2016)

“Complex Ancient Genetic Structure and Cultural Transitions in Southern African Populations”

The characterization of the structure of southern Africa populations has been the subject of numerous genetic, medical, linguistic, archaeological and anthropological investigations. Current diversity in the subcontinent is the result of complex events of genetic admixture and cultural contact between early inhabitants and migrants that arrived in the region over the last 2,000 years. Here we analyze 1,856 individuals from 91 populations, comprising novel and published genotype data, to characterize the genetic ancestry profiles of 631 individuals from 51 southern African populations. Combining both local ancestry and allele frequency based analyses we identify a tripartite, ancient, Khoesan-related genetic structure. This structure correlates neither with linguistic affiliation nor subsistence strategy, but with geography, revealing the importance of isolation by distance dynamics in the area. Fine-mapping of these components in southern African populations reveals that admixture and cultural reversion involving several Khoesan groups and highlights that Bantu speakers and Coloured individuals have different mixtures of these ancient ancestries.